New Era: Mavacamten for obstructive hypertrophic cardiomyopathy

ML Woodland, RA Al-Horani - Cardiovascular & Hematological …, 2023 - benthamdirect.com
Obstructive hypertrophic cardiomyopathy results from asymmetric septal hypertrophy, which
eventually obstructs the outflow of the left ventricle. Obstructive hypertrophic cardiomyopathy …

[HTML][HTML] Hypertrophic cardiomyopathy diagnosis and treatment in high-and low-income countries: a narrative review

EC Martinez, NY Ortiz-Garcia, DAH Hernandez… - Cureus, 2023 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is a hereditary cardiac condition characterized by
unexplained left ventricular hypertrophy without a hemodynamic cause. This condition is …

CSRP3, p. Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family

H Huang, Y Chen, J Jin, R Du, K Tang… - The Journal of Gene …, 2022 - Wiley Online Library
Background Hypertrophic cardiomyopathy (HCM) is a hereditary disease manifested by a
thickened ventricular wall. Cysteine and glycine‐rich protein 3 (CSRP3), the gene encoding …

The efficacy of cardiac myosin inhibitors versus placebo in patients with symptomatic hypertrophic cardiomyopathy: a meta-analysis and systematic review

M Yassen, K Changal, J Busken, R Royfman… - The American Journal of …, 2024 - Elsevier
We aimed to assess the overall clinical impact of cardiac myosin inhibitors in hypertrophic
cardiomyopathy (HCM). We performed a meta-analysis of published trials assessing the …

Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy

VN Rivas, AE Crofton, CE Jauregui, JR Wouters… - Scientific Reports, 2024 - nature.com
Hypertrophic cardiomyopathy (HCM) remains the most common cardiomyopathy in humans
and cats with few preclinical pharmacologic interventional studies. Small-molecule …

Current state of hypertrophic cardiomyopathy clinical trials

HH Khachfe, HA Salhab, MY Fares, HM Khachfe - Global heart, 2019 - Elsevier
Background Hypertrophic cardiomyopathy (HCM) is a genetic disorder with a very large
global burden for which more therapeutic management regimens are required. Objectives In …

Role of echocardiography in the diagnosis and management of hypertrophic cardiomyopathy

F Dominguez, E Gonzalez-Lopez, L Padron-Barthe… - Heart, 2018 - heart.bmj.com
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease,
affecting 1 in 500 individuals in the general population. In 60% of cases, HCM presents an …

Demystifying idiopathic interstitial pneumonia: time for more etiology-focused nomenclature in interstitial lung disease

NW Todd, SP Atamas, SE Hines, IG Luzina… - Expert review of …, 2022 - Taylor & Francis
Introduction A major focus of interstitial lung disease (ILD) has centered on disorders termed
idiopathic interstitial pneumonias (IIPs) which include, among others, idiopathic pulmonary …

The efficacy and safety of alcohol septal ablation stratified by alcohol dosage for patients with hypertrophic obstructive cardiomyopathy: a systematic review and meta …

A Elshahat, M Ellabban, AM Amin, A Diaa… - BMC Cardiovascular …, 2024 - Springer
Background Alcohol septal ablation (ASA) is recommended for moderate to severe
symptomatic patients with hypertrophic obstructive cardiomyopathy. The current guidelines …

[HTML][HTML] Adult Onset Hypertrophic Cardiomyopathy (HCM) Not Detected by Echocardiogram: A Case Presentation

KN Elsouri, JC Ramos, K Stepanek, A Turan… - Cureus, 2023 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease of the sarcomere
protein. The age of diagnosis of HCM tends to be between the second to third decades of …