Negative and ambisense RNA viruses are the causative agents of important human
diseases such as influenza, measles, Lassa fever, and Ebola hemorrhagic fever. The viral …

Defective viral genomes (DVGs) are truncated derivatives of their parental viral genomes
generated during an aberrant round of viral genomic replication. Distinct classes of DVGs …

Defective viral genomes (DVGs), which are generated by the viral polymerase in error
during RNA replication, can trigger innate immunity and are implicated in altering the clinical …

Negative-sense RNA viruses (NSVs) rely on prepackaged viral RNA-dependent RNA
polymerases (RdRp) to replicate and transcribe their viral genomes. Their replication …

Emerging viruses impose global threats to animal and human populations and may bear
novel genes with limited homology to known sequences, necessitating the development of …

Influenza A virus (IAV) contains a segmented RNA genome that is transcribed and replicated
by the viral RNA polymerase in the cell nucleus. Replicated RNA segments are assembled …

The influenza A virus genome is composed of eight single-stranded negative-sense viral
RNA segments (vRNAs). The eight vRNAs are selectively packaged into each progeny …

Deletion-containing viral genomes (DelVGs) are commonly produced during influenza A
virus infection and have been implicated in influencing clinical infection outcomes. Despite …

Influenza A virus (IAV) is a respiratory virus that causes epidemics and pandemics.
Knowledge of IAV RNA secondary structure in vivo is crucial for a better understanding of …

The eight different genomic viral RNAs (vRNAs) of influenza A virus are typically packaged
into virions as a (7+ 1) complex of seven viral ribonucleoproteins (vRNPs) around a central …