This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase,
and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human …

Homologous recombination is essential during meiosis in most sexually reproducing
organisms. In budding yeast, and most likely in other organisms as well, meiotic …

Meiosis is a special type of cell division that produces haploid gametes from diploid parental
cells. Chromosome number is reduced during meiosis because a single round of DNA …

When cells exit from mitotic cell division, their sister chromatids lose cohesion and separate
to opposite poles of the dividing cell, resulting in equational chromosome segregation. In …

▪ Abstract The leptotene/zygotene transition of meiosis, as defined by classical cytological
studies, is the period when homologous chromosomes, already being discernible …

Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic
chromosomes1, 2, are essential for complete replication3–5, and regulation of their length …

A bouquet makes ends meet | Nature Reviews Molecular Cell Biology Skip to main content
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Hepatocellular carcinoma (HCC) is one of the major cancers in the world. There is a striking
variation in HCC incidence rates between various countries, with a highest‐to‐lowest ratio of …