Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Capillary electrophoresis‐mass spectrometry (CE‐MS) is now a mature analytical technique
in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the …

As one of the most popular nutrient supplements, creatine has been highly used to increase
muscle mass and improve exercise performance. Here, we report an adverse effect of …

Mitochondrial quality in skeletal muscle is crucial for maintaining energy homeostasis during
metabolic stresses. However, how muscle mitochondrial quality is controlled and its …

Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and
acting as both protein quality surveillance and regulatory enzymes by performing highly …

Circular RNAs (circRNAs) have emerged as crucial regulators in physiology and human
diseases. However, evolutionarily conserved circRNAs with potent functions in cancers are …

Copper deficiency has emerged to be associated with various lipid metabolism diseases,
including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate …

Metabolite‐protein interactions (MPIs) play key roles in cancer metabolism. However, our
current knowledge about MPIs in cancers remains limited due to the complexity of cancer …

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
the third-leading cause of cancer-related mortality. Currently, the global burden of …

Metformin is the first-line antidiabetic drug that is widely used in the treatment of type 2
diabetes mellitus (T2DM). Even though the various therapeutic potential of metformin …