Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …
MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …
Disease-induced neuroinflammation and depression
Progression of major depression, a multifactorial disorder with a neuroinflammatory
signature, seems to be associated with the disruption of body allostasis. High rates of …
signature, seems to be associated with the disruption of body allostasis. High rates of …
Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice
FJ Kong, LL Ma, JJ Guo, LH Xu, Y Li, S Qu - Clinical Science, 2018 - portlandpress.com
Diabetes mellitus is a significant global public health problem depicting a rising prevalence
worldwide. As a serious complication of diabetes, diabetes-associated cognitive decline is …
worldwide. As a serious complication of diabetes, diabetes-associated cognitive decline is …
Phosphodiesterase inhibitors say NO to Alzheimer's disease
SM Nabavi, S Talarek, J Listos, SF Nabavi… - Food and Chemical …, 2019 - Elsevier
Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40
isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic …
isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic …
Characterization of white matter injury in a rat model of chronic cerebral hypoperfusion
Background and Purpose—Chronic cerebral hypoperfusion can lead to ischemic white
matter injury resulting in vascular dementia. To characterize white matter injury in vascular …
matter injury resulting in vascular dementia. To characterize white matter injury in vascular …
Cerebrovascular complications of diabetes: focus on cognitive dysfunction
The incidence of diabetes has more than doubled in the United States in the last 30 years
and the global disease rate is projected to double by 2030. Cognitive impairment has been …
and the global disease rate is projected to double by 2030. Cognitive impairment has been …
[HTML][HTML] Cerebral small vessel disease (CSVD)–lessons from the animal models
M Mustapha, CMNCM Nassir, N Aminuddin… - Frontiers in …, 2019 - frontiersin.org
Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …
resulting from pathological processes of various etiologies affecting cerebral arterioles …
Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation …
Y Zheng, J Zhang, Y Zhao, Y Zhang, X Zhang… - International …, 2021 - Elsevier
Background Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for
cognitive decline in vascular dementia (VaD). We have previously shown that diabetes …
cognitive decline in vascular dementia (VaD). We have previously shown that diabetes …
Physical exercise modulates the astrocytes polarization, promotes myelin debris clearance and remyelination in chronic cerebral hypoperfusion rats
T Jiang, J Luo, X Pan, H Zheng, H Yang, L Zhang, X Hu - Life sciences, 2021 - Elsevier
Aims White matter damage is the main pathological feature of chronic cerebral
hypoperfusion (CCH) and glial activation is crucial in this process. Physical exercise has …
hypoperfusion (CCH) and glial activation is crucial in this process. Physical exercise has …
High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion
Diabetes causes endothelial dysfunction and increases the risk of vascular cognitive
impairment. However, it is unknown whether diabetes causes cognitive impairment due to …
impairment. However, it is unknown whether diabetes causes cognitive impairment due to …