Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten
cases: known as Long COVID. The disease affects~ 65 million individuals worldwide. Many …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …