[HTML][HTML] Structural understanding of interleukin 6 family cytokine signaling and targeted therapies: focus on interleukin 11
Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …
[HTML][HTML] Autotaxin in pathophysiology and pulmonary fibrosis
I Ninou, C Magkrioti, V Aidinis - Frontiers in medicine, 2018 - frontiersin.org
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …
[HTML][HTML] The expression regulation and biological function of autotaxin
X Zhang, M Li, N Yin, J Zhang - Cells, 2021 - mdpi.com
Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …
[HTML][HTML] Commonalities between ARDS, pulmonary fibrosis and COVID-19: the potential of autotaxin as a therapeutic target
K Ntatsoulis, T Karampitsakos, E Tsitoura… - Frontiers in …, 2021 - frontiersin.org
Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like
hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ …
hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ …
[HTML][HTML] Lysophosphatidic acid signaling in obesity and insulin resistance
Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that
profoundly influences cellular signaling and function upon binding to G protein-coupled …
profoundly influences cellular signaling and function upon binding to G protein-coupled …
[HTML][HTML] Targeting lysophosphatidic acid in cancer: the issues in moving from bench to bedside
Y Xu - Cancers, 2019 - mdpi.com
Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …
[HTML][HTML] Coming of age for autotaxin and lysophosphatidate signaling: Clinical applications for preventing, detecting and targeting tumor-promoting inflammation
MGK Benesch, ITK MacIntyre, TPW McMullen… - Cancers, 2018 - mdpi.com
A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …
[HTML][HTML] Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism
K D'Souza, C Nzirorera, AM Cowie, GP Varghese… - Journal of lipid …, 2018 - ASBMB
Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid
(LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin …
(LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin …
[HTML][HTML] Increased autotaxin levels in severe COVID-19, correlating with IL-6 levels, endothelial dysfunction biomarkers, and impaired functions of dendritic cells
I Nikitopoulou, D Fanidis, K Ntatsoulis… - International Journal of …, 2021 - mdpi.com
Autotaxin (ATX; ENPP2) is a secreted lysophospholipase D catalyzing the extracellular
production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and …
production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and …
Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials
Several years after its isolation from melanoma cells, an increasing body of experimental
evidence has established the involvement of Autotaxin (ATX) in the pathogenesis of several …
evidence has established the involvement of Autotaxin (ATX) in the pathogenesis of several …