Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …

Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …

Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like
hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ …

Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that
profoundly influences cellular signaling and function upon binding to G protein-coupled …

Since the clear demonstration of lysophosphatidic acid (LPA)'s pathological roles in cancer
in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were …

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …

Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid
(LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin …

Autotaxin (ATX; ENPP2) is a secreted lysophospholipase D catalyzing the extracellular
production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and …

Several years after its isolation from melanoma cells, an increasing body of experimental
evidence has established the involvement of Autotaxin (ATX) in the pathogenesis of several …