Mosquito transgenesis for malaria control

S Dong, Y Dong, ML Simões, G Dimopoulos - Trends in parasitology, 2022 - cell.com
Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-
control methods, several novel mosquito vector-based control strategies have been …

Transmission-blocking strategies against malaria parasites during their mosquito stages

S Yu, J Wang, X Luo, H Zheng, L Wang… - Frontiers in cellular …, 2022 - frontiersin.org
Malaria is still the most widespread parasitic disease and causes the most infections
globally. Owing to improvements in sanitary conditions and various intervention measures …

CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

Y Dong, ML Simões, E Marois, G Dimopoulos - PLoS pathogens, 2018 - journals.plos.org
Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …

Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak/Stat Immune Pathways and Virus Host Factors

YI Angleró-Rodríguez, HJ MacLeod, S Kang… - Frontiers in …, 2017 - frontiersin.org
Zika (ZIKV) and dengue virus (DENV) are transmitted to humans by Aedes mosquitoes.
However, the molecular interactions between the vector and ZIKV remain largely …

Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

A Hoermann, T Habtewold, P Selvaraj… - Science …, 2022 - science.org
Gene drives hold promise for the genetic control of malaria vectors. The development of
vector population modification strategies hinges on the availability of effector mechanisms …

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

A Hoermann, S Tapanelli, P Capriotti, G Del Corsano… - Elife, 2021 - elifesciences.org
Gene drives for mosquito population replacement are promising tools for malaria control.
However, there is currently no clear pathway for safely testing such tools in endemic …

Transcriptomics of monarch butterflies (Danaus plexippus) reveals that toxic host plants alter expression of detoxification genes and down‐regulate a small number of …

WH Tan, T Acevedo, EV Harris, TY Alcaide… - Molecular …, 2019 - Wiley Online Library
Herbivorous insects have evolved many mechanisms to overcome plant chemical defences,
including detoxification and sequestration. Herbivores may also use toxic plants to reduce …

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

EO Adedeji, OO Ogunlana, S Fatumo, T Beder… - Parasites & vectors, 2020 - Springer
The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …

Use of insect promoters in genetic engineering to control mosquito-borne diseases

V Bottino-Rojas, AA James - Biomolecules, 2022 - mdpi.com
Mosquito transgenesis and gene-drive technologies provide the basis for developing
promising new tools for vector-borne disease prevention by either suppressing wild …

Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae

DA Ellis, G Avraam, A Hoermann, CAS Wyer… - PLoS …, 2022 - journals.plos.org
Gene drives for mosquito population modification are novel tools for malaria control.
Strategies to safely test antimalarial effectors in the field are required. Here, we modified the …