Mosquito transgenesis for malaria control
Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-
control methods, several novel mosquito vector-based control strategies have been …
control methods, several novel mosquito vector-based control strategies have been …
Transmission-blocking strategies against malaria parasites during their mosquito stages
S Yu, J Wang, X Luo, H Zheng, L Wang… - Frontiers in cellular …, 2022 - frontiersin.org
Malaria is still the most widespread parasitic disease and causes the most infections
globally. Owing to improvements in sanitary conditions and various intervention measures …
globally. Owing to improvements in sanitary conditions and various intervention measures …
CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection
Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …
and these agonists represent potent targets for transmission-blocking by either inhibiting or …
Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak/Stat Immune Pathways and Virus Host Factors
Zika (ZIKV) and dengue virus (DENV) are transmitted to humans by Aedes mosquitoes.
However, the molecular interactions between the vector and ZIKV remain largely …
However, the molecular interactions between the vector and ZIKV remain largely …
Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development
A Hoermann, T Habtewold, P Selvaraj… - Science …, 2022 - science.org
Gene drives hold promise for the genetic control of malaria vectors. The development of
vector population modification strategies hinges on the availability of effector mechanisms …
vector population modification strategies hinges on the availability of effector mechanisms …
Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement
A Hoermann, S Tapanelli, P Capriotti, G Del Corsano… - Elife, 2021 - elifesciences.org
Gene drives for mosquito population replacement are promising tools for malaria control.
However, there is currently no clear pathway for safely testing such tools in endemic …
However, there is currently no clear pathway for safely testing such tools in endemic …
Transcriptomics of monarch butterflies (Danaus plexippus) reveals that toxic host plants alter expression of detoxification genes and down‐regulate a small number of …
WH Tan, T Acevedo, EV Harris, TY Alcaide… - Molecular …, 2019 - Wiley Online Library
Herbivorous insects have evolved many mechanisms to overcome plant chemical defences,
including detoxification and sequestration. Herbivores may also use toxic plants to reduce …
including detoxification and sequestration. Herbivores may also use toxic plants to reduce …
Anopheles metabolic proteins in malaria transmission, prevention and control: a review
The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …
Use of insect promoters in genetic engineering to control mosquito-borne diseases
V Bottino-Rojas, AA James - Biomolecules, 2022 - mdpi.com
Mosquito transgenesis and gene-drive technologies provide the basis for developing
promising new tools for vector-borne disease prevention by either suppressing wild …
promising new tools for vector-borne disease prevention by either suppressing wild …
Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae
DA Ellis, G Avraam, A Hoermann, CAS Wyer… - PLoS …, 2022 - journals.plos.org
Gene drives for mosquito population modification are novel tools for malaria control.
Strategies to safely test antimalarial effectors in the field are required. Here, we modified the …
Strategies to safely test antimalarial effectors in the field are required. Here, we modified the …