Targeting cancer through recently developed purine clubbed heterocyclic scaffolds: An overview

A Chaurasiya, C Sahu, SK Wahan… - Journal of Molecular …, 2023 - Elsevier
Cancer is the world's major health issue, scavenging lives of millions throughout the world. A
number of anticancer drugs have figured prominently in the diagnosis and treatment of …

Modulation of Hedgehog signaling for the treatment of basal cell Carcinoma and the development of preclinical models

MW Dukes, TJ Meade - Biomedicines, 2022 - mdpi.com
Basal Cell Carcinoma (BCC) is the most commonly diagnosed cancer worldwide. While the
survivability of BCC is high, many patients are excluded from clinically available treatments …

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2, 6, 9-Trisubstituted Purine Derivatives as Potential Agents for …

J Bertrand, H Dostálová, V Kryštof, R Jorda, T Delgado… - Pharmaceutics, 2022 - mdpi.com
We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and
FLT3-ITD as part of our program to develop 2, 6, 9-trisubstituted purine derivatives as …

New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer

C Espinosa-Bustos, J Bertrand, A Villegas-Menares… - Bioorganic …, 2024 - Elsevier
Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the
development and progression of pancreatic cancer. For this reason, blockade of Hh pathway …

Molecular target and action mechanism of Anti-cancer agents

SG Lee - International Journal of Molecular Sciences, 2023 - mdpi.com
Precision oncology, also known as personalized medicine, is an evolving approach to
cancer treatment that aims to tailor therapies to individual patients based on their unique …

Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins

R Pai, DR Sirigiri, R Malempati, S Vinjamuri - PloS one, 2024 - journals.plos.org
Embryonic development in humans is controlled by the Hedgehog pathway, which becomes
inactive in mature tissues. Except for tissue maintenance and healing, activation of this …

Synthesis, antitumoral activity, and in silico studies on Smoothened receptor of new 2, 6, 9-trisubstituted purine derivatives

C Espinosa-Bustos, AM Zárate, A Castro-Álvarez… - Journal of Molecular …, 2025 - Elsevier
In this work, a series of 30 new 2, 6, 9-trisubstituted purine derivatives were synthesised and
evaluated in silico as potential ligands of the Smoothened (SMO) receptor, as well as their …

Phenoxy‐and Phenylamino‐Heterocyclic Quinones: Synthesis and Preliminary Anti‐Pancreatic Cancer Activity

P Sánchez, CO Salas… - Chemistry & …, 2022 - Wiley Online Library
The successful application of fragment‐based drug discovery strategy for the efficient
synthesis of phenoxy‐or phenylamino‐2‐phenyl‐benzofuran,‐benzoxazole and …

Synthesis of new nido-carborane-containing 6-thiopurine derivatives

AA Telegina, DA Gruzdev, GL Levit… - Russian Chemical …, 2023 - Springer
Synthesis of new nido-carborane-containing 6-thiopurines and thioguanines based on
nucleophilic substitution of the chlorine atom in the specially synthesized chloroacetyl …

Design, synthesis, and anti–tobacco mosaic virus activity evaluation of quinazolinone derivatives containing purine moieties

Y Deng, M Chen, J Yi, Y Zheng - Phytochemistry Letters, 2024 - Elsevier
In this study, a series of quinazolinone derivatives containing purine molecules were
designed and synthesized, and their structures were characterized by 1 H nuclear magnetic …