Nanocarriers (NCs) have shown potential in delivering hydrophobic cytotoxic drugs and
tumor-specific targeting. However, the inability to penetrate the tumor microenvironment and …

Extracellular vesicle DNAs (evDNAs) hold significant diagnostic value for various diseases
and facilitate transcellular transfer of genetic material. Our study identifies transcription factor …

Host factors provide critical support for every aspect of the virus life cycle. We recently
identified the valosin-containing protein (VCP)/p97, an abundant cellular ATPase with …

The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery
vehicles, but also by the inability of the small RNAs to reach intracellular compartments …

Density gradient centrifugation is a common method for separating intracellular organelles.
During centrifugation, organelles float or sediment until they reach their isopycnic position …

ADP-ribosylation factor 6 (ARF6) is a small GTPase that has a variety of neuronal functions
including stimulating neurite outgrowth, a crucial process for the establishment and …

Ras‐related C3 botulinum toxin substrate 1 (Rac1) is a member of the Rho family of
GTPases that functions as a molecular switch to regulate many important cellular events …

Unbound intrahepatic drug concentrations determine the interaction potential with
intracellular targets related to toxicity, pharmacokinetics, or pharmacodynamics. Recently …

Clearance (CL) prediction remains a significant challenge in drug discovery, especially
when complex processes such as drug transporters are involved. The present work explores …

Neutrophils, cells of the innate immune system, enter the mouth and release factors that are
hypothesized to contribute to the degradation of tooth dentin, methacrylate resin composites …