The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy.
The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated …

Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements
through mechanisms not always clear. Here, we demonstrate that the gatekeeper of …

The important role of mitochondria in cancer biology is gaining momentum. With their
regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other …

Mitochondrial Ca2+ uptake plays a pivotal role both in cell energy balance and in cell fate
determination. Studies on the role of mitochondrial Ca2+ signaling in pathophysiology have …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

Abstract Purpose: PI3K and STAT3 are frequently activated in cancer progression. However,
little is known about the underlying mechanisms by which PI3K and STAT3 regulate head …

Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient
availability, which is sustained by a metabolic reprograming now recognized as a hallmark …

Increasing evidence indicates that elevated expression of enhancer of zeste homolog 2
gene (EZH2) in many human malignant tumors acts a significant role in the oncogenic …

Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of
tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year …