Calcium sensors in neuronal function and dysfunction

RD Burgoyne, N Helassa… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

[HTML][HTML] NCS-1 is a regulator of calcium signaling in health and disease

GR Boeckel, BE Ehrlich - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …

Nanomolar affinity of EF-hands in neuronal calcium sensor 1 for bivalent cations Pb2+, Mn2+, and Hg2+

MS Alam, S Azam, K Pham, D Leyva, KJD Fouque… - Metallomics, 2022 - academic.oup.com
Abstract Abiogenic metals Pb and Hg are highly toxic since chronic and/or acute exposure
often leads to severe neuropathologies. Mn2+ is an essential metal ion but in excess can …

Neuronal Calcium Sensor 1 is up‐regulated in response to stress to promote cell survival and motility in cancer cells

HK Grosshans, TT Fischer, JA Steinle… - Molecular …, 2020 - Wiley Online Library
Changes in intracellular calcium (Ca2+) signaling can modulate cellular machinery required
for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed …

Exonic splicing code and protein binding sites for calcium

RJ Pengelly, D Bakhtiar, I Borovská… - Nucleic acids …, 2022 - academic.oup.com
Auxilliary splicing sequences in exons, known as enhancers (ESEs) and silencers (ESSs),
have been subject to strong selection pressures at the RNA and protein level. The protein …

[HTML][HTML] NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells

JC Sánchez, A Alemán, JF Henao, JC Olaya… - Journal of Physiology …, 2024 - Springer
The physical and functional interaction between transient receptor potential channel ankyrin
1 (TRPA1) and neuronal calcium sensor 1 (NCS-1) was assessed. NCS-1 is a calcium …

Ca2+‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha

D Takahashi, K Yonezawa, Y Okizaki… - Protein …, 2022 - Wiley Online Library
Diacylglycerol kinases (DGKs) are multi‐domain lipid kinases that modulate the levels of
lipid messengers, diacylglycerol, and phosphatidic acid. Recently, increasing attention has …

[HTML][HTML] A Novel Approach to Bacterial Expression and Purification of Myristoylated Forms of Neuronal Calcium Sensor Proteins

VI Vladimirov, VE Baksheeva, IV Mikhailova… - Biomolecules, 2020 - mdpi.com
N-terminal myristoylation is a common co-and post-translational modification of numerous
eukaryotic and viral proteins, which affects their interaction with lipids and partner proteins …

Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways

VE Baksheeva, AA Zamyatnin Jr, EY Zernii - Molecular Biology, 2023 - Springer
Intracellular calcium signaling is involved in regulating the key functional mechanisms of the
nervous system. The control of neuronal excitability and plasticity by calcium ions underlies …

Distinct mechanism of Tb 3+ and Eu 3+ binding to NCS1

MS Alam, D Leyva, W Michelin… - Physical Chemistry …, 2023 - pubs.rsc.org
Lanthanides have been frequently used as biomimetic compounds for NMR and
fluorescence studies of Ca2+ binding proteins due to having similar physical properties and …