Calcium sensors in neuronal function and dysfunction
RD Burgoyne, N Helassa… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …
[HTML][HTML] NCS-1 is a regulator of calcium signaling in health and disease
GR Boeckel, BE Ehrlich - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …
Nanomolar affinity of EF-hands in neuronal calcium sensor 1 for bivalent cations Pb2+, Mn2+, and Hg2+
Abstract Abiogenic metals Pb and Hg are highly toxic since chronic and/or acute exposure
often leads to severe neuropathologies. Mn2+ is an essential metal ion but in excess can …
often leads to severe neuropathologies. Mn2+ is an essential metal ion but in excess can …
Neuronal Calcium Sensor 1 is up‐regulated in response to stress to promote cell survival and motility in cancer cells
HK Grosshans, TT Fischer, JA Steinle… - Molecular …, 2020 - Wiley Online Library
Changes in intracellular calcium (Ca2+) signaling can modulate cellular machinery required
for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed …
for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed …
Exonic splicing code and protein binding sites for calcium
RJ Pengelly, D Bakhtiar, I Borovská… - Nucleic acids …, 2022 - academic.oup.com
Auxilliary splicing sequences in exons, known as enhancers (ESEs) and silencers (ESSs),
have been subject to strong selection pressures at the RNA and protein level. The protein …
have been subject to strong selection pressures at the RNA and protein level. The protein …
[HTML][HTML] NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
The physical and functional interaction between transient receptor potential channel ankyrin
1 (TRPA1) and neuronal calcium sensor 1 (NCS-1) was assessed. NCS-1 is a calcium …
1 (TRPA1) and neuronal calcium sensor 1 (NCS-1) was assessed. NCS-1 is a calcium …
Ca2+‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha
D Takahashi, K Yonezawa, Y Okizaki… - Protein …, 2022 - Wiley Online Library
Diacylglycerol kinases (DGKs) are multi‐domain lipid kinases that modulate the levels of
lipid messengers, diacylglycerol, and phosphatidic acid. Recently, increasing attention has …
lipid messengers, diacylglycerol, and phosphatidic acid. Recently, increasing attention has …
[HTML][HTML] A Novel Approach to Bacterial Expression and Purification of Myristoylated Forms of Neuronal Calcium Sensor Proteins
VI Vladimirov, VE Baksheeva, IV Mikhailova… - Biomolecules, 2020 - mdpi.com
N-terminal myristoylation is a common co-and post-translational modification of numerous
eukaryotic and viral proteins, which affects their interaction with lipids and partner proteins …
eukaryotic and viral proteins, which affects their interaction with lipids and partner proteins …
Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways
Intracellular calcium signaling is involved in regulating the key functional mechanisms of the
nervous system. The control of neuronal excitability and plasticity by calcium ions underlies …
nervous system. The control of neuronal excitability and plasticity by calcium ions underlies …
Distinct mechanism of Tb 3+ and Eu 3+ binding to NCS1
Lanthanides have been frequently used as biomimetic compounds for NMR and
fluorescence studies of Ca2+ binding proteins due to having similar physical properties and …
fluorescence studies of Ca2+ binding proteins due to having similar physical properties and …