Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Background: Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers
and has a poor prognosis. Recent studies have shown that copper-dependent, regulated …

Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …

Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …

Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-
ionophore, for copper deficiency disorders. However, we currently do not understand the …

Iron and copper are two essential metal elements in living systems, and their homeostasis is
extremely important to maintain normal biological activities. Deficiency or overload of these …

Copper is an essential metal nutrient for life that often relies on redox cycling between Cu (I)
and Cu (II) oxidation states to fulfill its physiological roles, but alterations in cellular redox …