More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …

Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key
step for the success of the in vitro production (IVP) of embryos. One of the known disruptors …

BACKGROUND Fertility loss during female ageing is associated with increasing basal FSH
and decreasing anti-Müllerian hormone (AMH) concentrations, together with compromised …

Exosomes are nano-sized structures that are found in semen, epididymal–fluid,
endometrium, as well as in follicular fluid. They are responsible for transporting bioactive …

During folliculogenesis, the oocyte and surrounding cumulus cells form an ensemble called
the cumulus-oocyte complex (COC). Due to their interdependence, research on the COC …

Communications are crucial to ovarian follicle development and to ovulation, and while both
folliculogenesis and oogenesis are distinct processes, they share highly interdependent …

Addition of follicular fluid to oocyte maturation medium can affect cumulus cell function,
increase competence of the oocytes to be fertilised and develop to the blastocyst stage and …

Significance: Four decades have passed since the first successful human embryo conceived
from a fertilization in vitro. Despite all advances, success rates in assisted reproduction …