Obesity has become a major epidemic in the 21st century. It increases the risk of
dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk …

Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

(1) Background: Recent individual studies have demonstrated that consumption of ultra-
processed food (UPF) may be related to type two diabetes mellitus (T2DM). We aimed to …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Obesity and metabolic syndrome are strongly associated with cancer, and these disorders
may share a common mechanism. Recently, fructose has emerged as a driving force to …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that
effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive
hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on …