The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …

Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …