Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

Macrophages are essential innate immune cells that contribute to host defense during
infection. An important feature of macrophages is their ability to respond to extracellular cues …

Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10
people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to …

Changes in metabolism of macrophages are required to sustain macrophage activation in
response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor …

Nonresolving inflammation is a critical driver of several chronic inflammatory diseases,
including inflammatory bowel diseases (IBD). This unresolved inflammation may result from …

Mucosal healing (MH) is vital in maintaining homeostasis within the gut and protecting
against injury and infections. Multiple factors and signaling pathways contribute in a …

Chronic inflammation poses challenges to effective cancer treatment. Although anti‐
inflammatory therapies have shown short‐term benefits, their long‐term implications may be …

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints that
affects~ 1% of the human population. Joint swelling and bone erosion, hallmarks of RA …

Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to
facilitate intercellular communication and promote the resolution of inflammation. However …

Despite significant recent therapeutic advances, complete mucosal healing remains a
difficult treatment target for many patients with inflammatory bowel diseases (IBD) to …