Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …

Cell-to-cell variability of gene expression in clonal populations of mammalian cells is
ubiquitous. However, because molecular biologists habitually assume uniformity of the cell …

Recent studies of microorganisms have revealed diverse complex social behaviors,
including cooperation in foraging, building, reproducing, dispersing and communicating …

Large populations of interacting active elements, periodic or chaotic, can undergo
spontaneous transitions to dynamically ordered states. These collective states are …

What is life? What type of system is life? How can we understand life? Or what does
“understanding life” really mean? Sixty years since the publication of What Is Life? by …

During development, cells undergo a unidirectional course of differentiation that
progressively decreases the number of cell types they can potentially become. Stem cells …

Stem cells do not all respond the same way, but the mechanisms underlying this
heterogeneity are not well understood. Here, we found that expression of Hes1 and its …

Many achievements in medicine have come from applying linear theory to problems. Most
current methods of data analysis use linear models, which are based on proportionality …

Improved biological and mechanical functionality of musculoskeletal tissue-engineered
constructs is required for clinical application, which can only be achieved by comprehensive …

The lack of understanding of stem cell differentiation and proliferation is a fundamental
problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell …