Objective The purpose of this paper is (1) to summarize what is known of factors that
inuence achieving the full genetic potential for skeletal mass, both positive and negative;(2) …

Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

Background Osteoporosis is a major public health problem of largely unknown cause. Loss-
of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 …

Osteoporosis is a complex disease that affects> 10 million people in the United States and
results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low …

Osteoporosis is a common multifactorial disorder of reduced bone mass. The disorder in its
most common form is generalized, affecting the elderly, both sexes, and all racial groups …

A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice
expressing this LRP5 mutation have a similar phenotype with high bone mass and …

Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Osteoporosis is a common disease with a strong genetic component characterised by low
bone mass, microarchitectural deterioration of bone tissue and an increased risk of fracture …

Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations.
Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have …