Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …

In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss
the innate and adaptive immune response generated by mRNA vaccines in different animal …

mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because
they are well tolerated, immunogenic, and scalable and are built on precise but adaptable …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Dendritic cells (DCs) are the sentinel antigen-presenting cells of the immune system; such
that their productive interface with the dying cancer cells is crucial for proper communication …

Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …

Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential
future beta-coronavirus infections is important for fighting possible future pandemics. Here …