The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth
muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …