Marine natural products play critical roles in the chemical defense of many marine
organisms and in some cases can influence the community structure of entire ecosystems …

Marine chemical ecology - Natural Product Reports (RSC Publishing) DOI:10.1039/B702742G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B702742G …

Bryostatin 1, a potent activator of protein kinase C epsilon (PKCɛ), has been shown to
reverse synaptic loss and facilitate synaptic maturation in animal models of Alzheimer's …

The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach
based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L …

Context: Bryostatins represent an important group of pharmaceutically promising
substances. These compounds are produced by commensal microorganisms naturally …

C1 domains are small zinc-binding structural units of approximately 50 amino acid residues,
originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. Although …

Abstract In this Focus Review, we give an overview of various bryostatin total syntheses. We
also discuss the synthesis of various bryostatin analogues and their biological activity. Work …

Modern methods for the identification of therapeutic leads include chemical or virtual
screening of compound libraries. Nature's library represents a vast and diverse source of …

Protein kinase C (PKC) activators possess potent neurotrophic and neuroprotective activity,
thus indicating potential applications in treating neurodegenerative diseases, stroke and …

Covering: up to the end of 2014 Polyketides represent an important class of secondary
metabolites that interact with biological targets connected to a variety of disease-associated …