Background Understanding molecular pathogenesis of head and neck squamous cell
carcinomas (HNSCC) has considerably improved in the last decades. As a result, novel …

Delay in the assessment of tumor response to radiotherapy continues to pose a major
challenge to quality of life for patients with nonresponsive tumors. Here, we exploited label …

Intracellular pathogens have evolved to utilize normal cellular processes to complete their
replicative cycles. Pathogens that interface with proliferative cell signaling pathways risk …

Head and neck squamous cell carcinomas (HNSCC) are frequently altered along the
PI3K/AKT/mTORC signaling axis. Despite excellent preclinical data, the use of compounds …

Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain
elusive. The BRAF mutation V600E is critical to the pathogenesis of 10–20% of pediatric …

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma
(HNSCC), however, radioresistance remains a major clinical problem despite significant …

Human immunodeficiency virus (HIV) infection is strongly associated with a heightened
incidence of lymphomas. To mirror the natural course of human HIV infection, animal models …

Non-small cell lung cancer (NSCLC) brain metastasis cell lines and in vivo models are not
widely accessible. Herein we report on a direct-from patient-derived xenograft (PDX) model …

The epidermal growth factor receptor (EGFR) is a therapeutic target in head and neck
squamous cell carcinoma (HNSCC). Resistance to EGFR-targeted therapies, such as …

There is a critical need to identify patients with radiation-resistant tumors early after
treatment commencement. In this study, we use diffuse reflectance spectroscopy (DRS) to …