The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Immunoregulatory networks in human C hagas disease

WO Dutra, CAS Menezes, LMD Magalhães… - Parasite …, 2014 - Wiley Online Library
Chagas disease, caused by the infection with T rypanosoma cruzi, is endemic in all L atin A
merica. Due to the increase in population migration, C hagas disease has spread worldwide …

Chagas disease diagnostic applications: present knowledge and future steps

V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

[HTML][HTML] Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

AVM Ferreira, M Segatto, Z Menezes, AM Macedo… - Microbes and …, 2011 - Elsevier
Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental
animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue …

Multiplex Real-Time PCR Assay Using TaqMan Probes for the Identification of Trypanosoma cruzi DTUs in Biological and Clinical Samples

CI Cura, T Duffy, RH Lucero, M Bisio… - PLoS neglected …, 2015 - journals.plos.org
Background Trypanosoma cruzi has been classified into six Discrete Typing Units (DTUs),
designated as TcI–TcVI. In order to effectively use this standardized nomenclature, a …

Ecological scenario and Trypanosoma cruzi DTU characterization of a fatal acute Chagas disease case transmitted orally (Espírito Santo state, Brazil)

MA Dario, MS Rodrigues, JHS Barros, SCC Xavier… - Parasites & …, 2016 - Springer
Background Trypanosoma cruzi infection via oral route results in outbreaks or cases of acute
Chagas disease (ACD) in different Brazilian regions and poses a novel epidemiological …

Putting infection dynamics at the heart of Chagas disease

MD Lewis, JM Kelly - Trends in parasitology, 2016 - cell.com
In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but
nonsterilising immune responses. Infected cells are difficult to detect because they are …

Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU

JL Reis-Cunha, RP Baptista, GF Rodrigues-Luiz… - BMC genomics, 2018 - Springer
Background Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided
into six discrete typing units (DTUs), named TcI-TcVI. TcII is among the major DTUs enrolled …

A Simple Strain Typing Assay for Trypanosoma cruzi: Discrimination of Major Evolutionary Lineages from a Single Amplification Product

RO Cosentino, F Agüero - 2012 - journals.plos.org
Background Trypanosoma cruzi is the causative agent of Chagas' Disease. The parasite has
a complex population structure, with six major evolutionary lineages, some of which have …