Memory engrams: Recalling the past and imagining the future
SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …
The oxytocin receptor: from intracellular signaling to behavior
B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
Norepinephrine links astrocytic activity to regulation of cortical state
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
Reversing a model of Parkinson's disease with in situ converted nigral neurons
Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra.
Similar to other major neurodegenerative disorders, there are no disease-modifying …
Similar to other major neurodegenerative disorders, there are no disease-modifying …
[HTML][HTML] Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture
S Liu, ZF Wang, YS Su, RS Ray, XH Jing, YQ Wang… - Neuron, 2020 - cell.com
The neuroanatomical basis behind acupuncture practice is still poorly understood. Here, we
used intersectional genetic strategy to ablate NPY+ noradrenergic neurons and/or adrenal …
used intersectional genetic strategy to ablate NPY+ noradrenergic neurons and/or adrenal …
Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
The chemogenetic technology DREADD (designer receptors exclusively activated by
designer drugs) is widely used for remote manipulation of neuronal activity in freely moving …
designer drugs) is widely used for remote manipulation of neuronal activity in freely moving …
Biased signalling: from simple switches to allosteric microprocessors
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …
genome and some of the most common drug targets. It is now well established that GPCRs …
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …
[HTML][HTML] Illuminating G-protein-coupling selectivity of GPCRs
Heterotrimetic G proteins consist of four subfamilies (G s, G i/o, G q/11, and G 12/13) that
mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding …
mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding …