Aquatic and terrestrial environments are increasingly contaminated by anthropogenic
sources that include pharmaceuticals, personal care products, and industrial and …

Thyroid hormone (TH) is the most important hormone in frog metamorphosis, a
developmental process which will not occur in the absence of TH but can be induced …

Frogs play important ecological roles, and several species are important model organisms
for scientific research. The globally distributed Ranidae (true frogs) are the largest frog …

Thyroid hormones exert a broad influence on brain development and function, which has
been extensively studied over the years. Mouse genetics has brought an important …

Abstract Model animals are crucial to biomedical research. Among the commonly used
model animals, the amphibian, Xenopus, has had tremendous impact because of its unique …

Thyroid hormone (TH) signaling comprises TH transport across cell membranes, metabolism
by deiodinases, and molecular mechanisms of gene regulation. Proper TH signaling is …

Background: Most work in endocrinology focus on the action of a single hormone, and very
little on the cross-talks between two hormones. Here we characterize the nature of …

Mammalian brain development critically depends on proper thyroid hormone signaling, via
the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain …

Thyroid hormone (T3) affects development and metabolism in vertebrates. We have been
studying intestinal remodeling during T3-dependent Xenopus metamorphosis as a model for …

Thyroid hormone is essential for normal development in vertebrates. In amphibians, T3
controls metamorphosis by inducing tissue-specific gene regulation programs. A hallmark of …