Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage
Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular
endothelial growth factor receptors (VEGFRs) have been associated with OA severity …
endothelial growth factor receptors (VEGFRs) have been associated with OA severity …
Skeletal interoception in osteoarthritis
The interoception maintains proper physiological conditions and metabolic homeostasis by
releasing regulatory signals after perceving changes in the internal state of the organism …
releasing regulatory signals after perceving changes in the internal state of the organism …
[HTML][HTML] Neural and immune roles in osteoarthritis pain: Mechanisms and intervention strategies
Y Zou, C Liu, Z Wang, G Li, J Xiao - Journal of Orthopaedic Translation, 2024 - Elsevier
Pain is the leading symptom for most individuals with osteoarthritis (OA), a complex
condition marked by joint discomfort. Recently, the dynamic interplay between the nervous …
condition marked by joint discomfort. Recently, the dynamic interplay between the nervous …
[HTML][HTML] Targeting vascular endothelial growth factor receptors as a therapeutic strategy for osteoarthritis and associated pain
Pain is the major reason that patients suffering from osteoarthritis (OA) seek medical care.
We found that vascular endothelial growth factors (VEGFs) mediate signaling in OA pain …
We found that vascular endothelial growth factors (VEGFs) mediate signaling in OA pain …
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice
Chronic pain is a prevalent problem that plagues modern society, and better understanding
its mechanisms is critical for developing effective therapeutics. Nerve growth factor (NGF) …
its mechanisms is critical for developing effective therapeutics. Nerve growth factor (NGF) …
[HTML][HTML] Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases
Many routes may lead to the transition from a healthy to a diseased phenotype. However,
there are not so many routes to travel in the opposite direction; that is, therapy for different …
there are not so many routes to travel in the opposite direction; that is, therapy for different …
Recent research advances in pain mechanisms in McCune–Albright syndrome thinking about the pain mechanism of FD/MAS
Y Wang, T Jiang - Journal of Orthopaedic Surgery and Research, 2024 - Springer
Background The lack of effective understanding of the pain mechanism of McCune–Albright
syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge …
syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge …
Suppression of CGRP and TRPV1 Expression in Dorsal Root Ganglia of Knee Osteoarthritis Rats by Huojing Decoction via TrkA/MKK3/6/p38 Pathway
X Jiang, Y Guo, M Fang, X Wang, B Zhang… - Journal of …, 2024 - Taylor & Francis
Objective Knee osteoarthritis (KOA) is a chronic condition characterized by persistent pain
that can lead to severe disability. In this study, we primarily investigated the analgesic effect …
that can lead to severe disability. In this study, we primarily investigated the analgesic effect …
Nerve growth factor monoclonal antibody Tanezumab alleviates Kashin-Beck Disease Rat pain by impacting DRG signal transduction
W Haifan, H Yigeng, Y Weiming, Z Qinfeng, L Sen… - 2023 - researchsquare.com
Method After the establishment of KBD models in SD rats, the rats were injected with the
NGF monoclonal antibody Tanezumab (Tnz) at doses of 2.5 and 5.0 mg/kg every week …
NGF monoclonal antibody Tanezumab (Tnz) at doses of 2.5 and 5.0 mg/kg every week …