Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …
motor neurons. As with all major neurodegenerative disorders, development of disease …
[HTML][HTML] Non-neuronal cells in amyotrophic lateral sclerosis—from pathogenesis to biomarkers
The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications
J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
CP Webster, EF Smith, CS Bauer, A Moller… - The EMBO …, 2016 - embopress.org
A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS/FTD) …
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS/FTD) …
Astrocytes in neurodegenerative disease
H Phatnani, T Maniatis - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Astrocytes contribute to the maintenance of the health and function of the central nervous
system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated …
system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated …
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
J Nijssen, LH Comley, E Hedlund - Acta neuropathologica, 2017 - Springer
In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …
Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain
R Vieira, JN Mariani, NPT Huynh… - Nature …, 2024 - nature.com
Competition among adult brain cells has not been extensively researched. To investigate
whether healthy glia can outcompete diseased human glia in the adult forebrain, we …
whether healthy glia can outcompete diseased human glia in the adult forebrain, we …
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states
Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but
whether they adopt deleterious features consistent with inflammatory reactive states remains …
whether they adopt deleterious features consistent with inflammatory reactive states remains …
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
The human cerebral cortex develops through an elaborate succession of cellular events
that, when disrupted, can lead to neuropsychiatric disease. The ability to reprogram somatic …
that, when disrupted, can lead to neuropsychiatric disease. The ability to reprogram somatic …
[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …