[HTML][HTML] Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children

CE Rogers, RE Lean, MD Wheelock… - Journal of …, 2018 - Springer
Background Despite advances in antenatal and neonatal care, preterm birth remains a
leading cause of neurological disabilities in children. Infants born prematurely, particularly …

Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity

TP Beauchaine, JN Constantino - Biomarkers in medicine, 2017 - Taylor & Francis
In psychopathology research, endophenotypes are a subset of biomarkers that indicate
genetic vulnerability independent of clinical state. To date, an explicit expectation is that …

Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility

MN Meyer, PS Appelbaum, DJ Benjamin… - Hastings Center …, 2023 - Wiley Online Library
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …

Irritability as a transdiagnostic vulnerability trait: Current issues and future directions

TP Beauchaine, JL Tackett - Behavior therapy, 2020 - Elsevier
In recent years, irritability has received increasing attention among mental health
professionals given its transdiagnostic associations with diverse forms of psychopathology …

Clinical and translational implications of an emerging developmental substructure for autism

JN Constantino, T Charman… - Annual review of clinical …, 2021 - annualreviews.org
A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A
growing number of studies in the past five years have indicated that inherited susceptibility …

RDoC and psychopathology among youth: Misplaced assumptions and an agenda for future research

TP Beauchaine, SP Hinshaw - Journal of clinical child & …, 2020 - Taylor & Francis
Now over 10 years old, the Research Domain Criteria (RDoC) has gained impressive
traction in the adult psychopathology literature, but enthusiasm among child and adolescent …

Identification of neuropsychiatric copy number variants in a health care system population

CL Martin, KE Wain, MT Oetjens, K Tolwinski… - JAMA …, 2020 - jamanetwork.com
Importance Population screening for medically relevant genomic variants that cause
diseases such as hereditary cancer and cardiovascular disorders is increasing to facilitate …

Linking social motivation with social skill: The role of emotion dysregulation in autism spectrum disorder

E Neuhaus, SJ Webb, RA Bernier - Development and …, 2019 - cambridge.org
Autism spectrum disorder (ASD) is associated with pervasive social deficits as well as
marked emotion dysregulation across the life span. Decreased social motivation accounts in …

Psychiatry and developmental psychopathology: Unifying themes and future directions

TP Beauchaine, JN Constantino, EP Hayden - Comprehensive psychiatry, 2018 - Elsevier
In the past 35 years, developmental psychopathology has grown into a flourishing discipline
that shares a scientific agenda with contemporary psychiatry. In this editorial, which …

Deconstructing autism: from unitary syndrome to contributory developmental endophenotypes

JN Constantino - International Review of Psychiatry, 2018 - Taylor & Francis
A recent generation of family studies has revealed that autism can be predicted from an
array of neurobehavioural susceptibilities that are appreciable before the syndrome is …