Almost all drug molecules become the substrates for oxidoreductase enzymes, get
metabolized into more hydrophilic products and eliminated from the body. These …

Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a
privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into …

Abstract Novel thiazolidine-2, 4-dione derivatives, 11a-g, were designed, and synthesized
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …

Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines and their
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …

A series of novel substituted 2-(4-bromophenyl)-4-phenylthiazole compounds 5a–h were
synthesized by a simplified two-step process. First, the selective and effective α-bromination …

We herein report the design, synthesis and molecular docking studies of 2, 4-
thiazolidinedione derivatives containing benzene sulphonyl group which are docked against …

In an attempt to develop novel α-amylase inhibitors, a series of 2, 4-thiazolidinedione fused
spiropyrrolidine-oxindole and 1, 2, 3-triazole scaffolds were designed, synthesized via a …

A novel series of (Z)-3, 5-disubstituted thiazolidine-2, 4-diones 4–16 has been designed and
synthesized. Preliminary screening of these compounds for their anti-breast cancer activity …

2, 4-Thiazolidinedione (2, 4-TZD) is a versatile pharmacophore, a privileged scaffold, and a
remarkable sulphur-containing heterocyclic compound with diverse pharmacological …

The present work describes the synthesis of new series of 5‐arylidene‐thiazolidine‐2, 4‐
dione, thieno [2, 3‐d] pyrimidine‐6‐carboxylate derivatives 9 a–o. A variety of spectroscopic …