[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
[HTML][HTML] DNA alkylation damage by nitrosamines and relevant DNA repair pathways
J Fahrer, M Christmann - International journal of molecular sciences, 2023 - mdpi.com
Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …
and can arise endogenously. More recently, nitrosamines have been detected as impurities …
Potential environmental health risk analysis of neonicotinoids and a synergist
L Xu, X Xu, L Guo, Z Wang, X Wu… - … Science & Technology, 2021 - ACS Publications
The extensive use of neonicotinoid pesticides has led to their widespread presence in the
environment, resulting in considerable safety risks to the ecosystem and human health. In …
environment, resulting in considerable safety risks to the ecosystem and human health. In …
[HTML][HTML] Recent studies on DNA adducts resulting from human exposure to tobacco smoke
B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …
smokers and are proposed as being potential biomarkers of cancer risk. We have …
[HTML][HTML] Chemical analysis of DNA damage
In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …
and exogenous chemical agents that can induce DNA damage. To counteract the …
A review of stable isotope labeling and mass spectrometry methods to distinguish exogenous from endogenous DNA adducts and improve dose–response …
Cancer remains the second most frequent cause of death in human populations worldwide,
which has been reflected in the emphasis placed on management of risk from environmental …
which has been reflected in the emphasis placed on management of risk from environmental …
[HTML][HTML] Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells
The tobacco-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N′-nitrosonornicotine (NNN) are known human carcinogens. Following metabolic …
and N′-nitrosonornicotine (NNN) are known human carcinogens. Following metabolic …
Recent developments in DNA adduct analysis using liquid chromatography coupled with mass spectrometry
Y Tang, JL Zhang - Journal of separation science, 2020 - Wiley Online Library
The formation of DNA adducts by genotoxic agents is an early event in cancer development,
and it may lead to gene mutations, thereby initiating tumor development. The measurement …
and it may lead to gene mutations, thereby initiating tumor development. The measurement …
Face mask as a versatile sampling device for the assessment of personal exposure to 54 toxic compounds in environmental tobacco smoke
Exposure to environmental tobacco smoke (ETS), which contains hundreds of toxic
compounds, significantly increases the risk of developing many human diseases, including …
compounds, significantly increases the risk of developing many human diseases, including …
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism
The International Agency for Research on Cancer has classified the tobacco-specific
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …