The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

Cytokinesis is a temporally and spatially regulated process through which the cellular
constituents of the mother cell are partitioned into two daughter cells, permitting an increase …

A conserved signalling cascade—termed the mitotic-exit network in budding yeast and the
septation-initiation network in fission yeast—controls key events during exit from mitosis and …

Bfa1p and Bub2p are spindle checkpoint proteins that likely have GTPase activation activity
and are associated with the budding yeast spindle pole body (SPB). Here, we show that …

Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in
response to a signal generated by mitotic spindle damage or by chromosomes that have not …

The spindle assembly checkpoint monitors proper chromosome attachment to spindle
microtubules and is conserved from yeast to humans. Checkpoint components reside on …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …

Checkpoints help ensure that cell cycle events occur in the correct order. Studies on
mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases …

Centrosomes, spindle pole bodies, and related structures in other organisms are a
morphologically diverse group of organelles that share a common ability to nucleate and …

Little is known about the mechanisms that establish the position of the division plane in
eukaryotic cells. Wild-type fission yeast cells divide by forming a septum in the middle of the …