The endoplasmic reticulum (ER) is an important site for protein folding and maturation in
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

Abstract Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution
of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied …

Bacteria come in a range of shapes, including round, rod-shaped, curved and spiral cells.
This morphological diversity implies that different mechanisms exist to guide proper cell …

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …

Systematic and quantitative analysis of protein phosphorylation is revealing dynamic
regulatory networks underlying cellular responses to environmental cues. However …

Ire1 (Ern1) is an unusual transmembrane protein kinase essential for the endoplasmic
reticulum (ER) unfolded protein response (UPR). Activation of Ire1 by association of its N …

Tank-binding kinase (TBK) 1 plays a central role in innate immunity: it serves as an
integrator of multiple signals induced by receptor-mediated pathogen detection and as a …

The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …

Tank-binding kinase 1 (TBK1) serves as an important component of multiple signaling
pathways. While the majority of research on TBK1 has focused on its role in innate immunity …