The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …

Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …

Human infectious diseases are unique in that the discovery of their environmental trigger,
the microbe, was sufficient to drive the development of extraordinarily effective principles …

The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here,
we trace the development of these autoantibodies at high-resolution using longitudinal …

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …