The single-stranded DNA-binding protein (SSB) of Escherichia coli is involved in all aspects
of DNA metabolism: replication, repair, and recombination. In solution, the protein exists as a …

Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to
delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest …

A study was conducted to determine the fidelity of DNA synthesis catalyzed in vitro by the
reverse transcriptase from a human immunodeficiency virus type 1 (HIV-1). Like other …

The human immunodeficiency virus type 1 (HIV-1) shows extensive genetic variation and
undergoes rapid evolution. The fidelity of purified HIV-1 reverse transcriptase was measured …

DNA polymerases catalyze the addition of deoxyribonucleotides onto DNA primers in a
template-directed manner. The requirement for template instruction distinguishes these …

The mechanism of replication of the simian virus 40 (SV40) genome closely resembles that
of cellular chromosomes, thereby providing an excellent model system for examining the …

The human genome encodes at least 14 DNA-dependent DNA polymerases—a surprisingly
large number. These include the more abundant, high-fidelity enzymes that replicate the …

Pulse-chase experiments have revealed that cyclin, the auxiliary protein of DNA polymerase-
delta, is stable during the transition from growth to quiescence in 3T3 cells. Immunoblotting …

DNA polymerases are indispensable for maintaining the integrity of the genome, both
through faithful replication of DNA and by repairing damage to DNA. Among the 16 highly …

Compounds of lead and cadmium have been shown to be carcinogenic to humans and
experimental animals. However, the underlying mechanisms are still not understood. In …