Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

The anaphase-promoting complex or cyclosome (APC/C) is the ubiquitin ligase that
regulates mitosis by targeting specific proteins for degradation at specific times under the …

Faithful chromosome segregation during mitosis is essential for genome integrity and is
mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules …

In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a
highly stereotypical manner, with each sister kinetochore forming microtubule attachments to …

Replication stress, a hallmark of cancerous and pre-cancerous lesions, is linked to structural
chromosomal aberrations. Recent studies demonstrated that it could also lead to numerical …

Intercellular heterogeneity, exacerbated by chromosomal instability (CIN), fosters tumor
heterogeneity and drug resistance. However, extreme CIN correlates with improved cancer …

Mitosis requires extensive rearrangement of cellular architecture and of subcellular
structures so that replicated chromosomes can bind correctly to spindle microtubules and …

Control of stem cell behaviors at solid biointerfaces is critical for stem-cell-based
regeneration and generally achieved by engineering chemical composition, topography …