Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and a
progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Objective: To describe an in vivo model in the rat in which change in weight distribution is
used as a measure of disease progression and efficacy of acetaminophen and two …

Accumulating evidence suggests that activation of spinal microglia contributes to the
development of inflammatory and neuropathic pain. However, the role of spinal microglia in …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

A characteristic symptom of neuropathic pain is mechanical allodynia. In animal models of
neuropathic pain, mechanical allodynia is often assessed using von Frey filaments …