Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

JM McPartland, M Duncan, V Di Marzo… - British journal of …, 2015 - Wiley Online Library
Based upon evidence that the therapeutic properties of C annabis preparations are not
solely dependent upon the presence of Δ9‐tetrahydrocannabinol (THC), pharmacological …

[HTML][HTML] Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol

DL Boggs, JD Nguyen, D Morgenson… - …, 2018 - nature.com
The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its
psychotropic and mind-altering side effects for millennia. There has been growing attention …

[HTML][HTML] In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

G Watt, T Karl - Frontiers in pharmacology, 2017 - frontiersin.org
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is affecting an
increasing number of people. It is characterized by the accumulation of amyloid-β and tau …

[HTML][HTML] Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD

J Han, P Kesner, M Metna-Laurent, T Duan, L Xu… - Cell, 2012 - cell.com
Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

[HTML][HTML] Opposite effects of Δ-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

S Bhattacharyya, PD Morrison, P Fusar-Poli… - …, 2010 - nature.com
Abstract Δ-9-tetrahydrocannabinol (Δ-9-THC) and Cannabidiol (CBD), the two main
ingredients of the Cannabis sativa plant have distinct symptomatic and behavioral effects …

A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

E Russo, GW Guy - Medical hypotheses, 2006 - Elsevier
This study examines the current knowledge of physiological and clinical effects of
tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their …

What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance?

MJ Fernandez-Serrano, M Pérez-García… - Neuroscience & …, 2011 - Elsevier
Most substance abusers simultaneously use and abuse more than one substance, even
when there is a clear drug of choice. This pattern creates a great challenge in relating …

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

AC Campos, Z Ortega, J Palazuelos… - International Journal …, 2013 - academic.oup.com
Cannabidiol (CBD), the main non-psychotomimetic component of the plant Cannabis sativa,
exerts therapeutically promising effects on human mental health such as inhibition of …

[HTML][HTML] Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic

E Aso, I Ferrer - Frontiers in pharmacology, 2014 - frontiersin.org
The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights
the need for intensifying research efforts devoted to developing new agents for preventing or …

5‐HT1A receptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

LBM Resstel, RF Tavares, SFS Lisboa… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Cannabidiol (CBD) is a non‐psychotomimetic compound from
Cannabis sativa which induces anxiolytic‐and antipsychotic‐like effects in rodents. These …