[HTML][HTML] Immune checkpoint inhibitors in cancer therapy
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
[HTML][HTML] The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives
S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …
correspondence between disease mortality and incidence. Furthermore, it is usually …
[HTML][HTML] Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling
The tumor microbiome is increasingly implicated in cancer progression and resistance to
chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of …
chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of …
[HTML][HTML] Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …
complex ecosystem that drives tumor progression; however, in-depth single cell …
[HTML][HTML] Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review
R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …
exponentially since these two diseases were recognized as important risk factors for …
[HTML][HTML] Pancreatic cancer and cellular senescence: tumor microenvironment under the spotlight
Pancreatic ductal adenocarcinoma (PDAC) has one of the most dismal prognoses of all
cancers due to its late manifestation and resistance to current therapies. Accumulating …
cancers due to its late manifestation and resistance to current therapies. Accumulating …
Changes in tissue fluidity predict tumor aggressiveness in vivo
F Sauer, S Grosser, M Shahryari, A Hayn… - Advanced …, 2023 - Wiley Online Library
Cancer progression is caused by genetic changes and associated with various alterations in
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
[HTML][HTML] HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation
High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors
where they portend adverse outcomes, although how they function in cancer remains …
where they portend adverse outcomes, although how they function in cancer remains …
[HTML][HTML] Fibroblasts as turned agents in cancer progression
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …
an ecosystem made up of a variety of cells and proteins that support their intended functions …