Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment
Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries
GJ Martinez, M Appleton, ZA Kipp… - Physiological …, 2024 - journals.physiology.org
The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …
Matrix metalloproteinase-9 as an important contributor to the pathophysiology of depression
Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …
Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention
M Walaszek, Z Kachlik, WJ Cubała - Nutritional Neuroscience, 2024 - Taylor & Francis
Objectives: Mood disorders are trending to be among the leading causes of years lived with
disability. Despite multiple treatment options, around 30% patients with major depressive …
disability. Despite multiple treatment options, around 30% patients with major depressive …
Neuropathic pain; what we know and what we should do about it
PA Smith - Frontiers in Pain Research, 2023 - frontiersin.org
Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
Neurotrophin signaling impairment by viral infections in the central nervous system
K Bohmwald, CA Andrade, VP Mora, JT Muñoz… - International Journal of …, 2022 - mdpi.com
Neurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important …
and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important …
Cell type–specific methylome-wide association studies implicate neurotrophin and innate immune signaling in major depressive disorder
Background We sought to characterize methylation changes in brain and blood associated
with major depressive disorder (MDD). As analyses of bulk tissue may obscure association …
with major depressive disorder (MDD). As analyses of bulk tissue may obscure association …
Lower nerve growth factor levels in major depression and suicidal behaviors: effects of adverse childhood experiences and recurrence of illness
M Maes, M Rachayon, K Jirakran, P Sodsai… - Brain Sciences, 2023 - mdpi.com
Major depressive disorder (MDD) and its severe subtype, major dysmood disorder (MDMD),
are distinguished by activation of inflammatory and growth factor subnetworks, which are …
are distinguished by activation of inflammatory and growth factor subnetworks, which are …
Intercellular signaling by ectodomain shedding at the synapse
MD Martín-de-Saavedra, M Dos Santos… - Trends in neurosciences, 2022 - cell.com
Ectodomain shedding (ES) is a post-translational protein modification process that plays key
roles in health and disease. Many neuronal and synaptic membrane proteins are known to …
roles in health and disease. Many neuronal and synaptic membrane proteins are known to …
The role of pro-and mature neurotrophins in the depression
Y Xue, H Liang, R Yang, K Deng, M Tang… - Behavioural Brain …, 2021 - Elsevier
Neurotrophic factors, which can provide nutritional support to neurons and neuronal cells,
also played an important role in their proliferation and survival. As signaling molecules, it …
also played an important role in their proliferation and survival. As signaling molecules, it …