Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …

Objectives: Mood disorders are trending to be among the leading causes of years lived with
disability. Despite multiple treatment options, around 30% patients with major depressive …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Neurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important …

Background We sought to characterize methylation changes in brain and blood associated
with major depressive disorder (MDD). As analyses of bulk tissue may obscure association …

Major depressive disorder (MDD) and its severe subtype, major dysmood disorder (MDMD),
are distinguished by activation of inflammatory and growth factor subnetworks, which are …

Ectodomain shedding (ES) is a post-translational protein modification process that plays key
roles in health and disease. Many neuronal and synaptic membrane proteins are known to …

Neurotrophic factors, which can provide nutritional support to neurons and neuronal cells,
also played an important role in their proliferation and survival. As signaling molecules, it …