Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
Molecular architecture of the mammalian circadian clock
CL Partch, CB Green, JS Takahashi - Trends in cell biology, 2014 - cell.com
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …
temporal homeostasis with the external environment. The molecular clocks that drive these …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
New insights into the circadian rhythm and its related diseases
Y Xie, Q Tang, G Chen, M Xie, S Yu, J Zhao… - Frontiers in …, 2019 - frontiersin.org
Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …
the molecular circadian clock which acting on coordinating internal time with the external …
Molecular components of the Mammalian circadian clock
ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …
the environment. This is achieved by ocular photoreception relaying signals to the …
Identification of small molecule activators of cryptochrome
Impairment of the circadian clock has been associated with numerous disorders, including
metabolic disease. Although small molecules that modulate clock function might offer …
metabolic disease. Although small molecules that modulate clock function might offer …
Genetics of circadian rhythms in Mammalian model organisms
PL Lowrey, JS Takahashi - Advances in genetics, 2011 - Elsevier
The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
Circadian rhythms persist without transcription in a eukaryote
Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of
behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and …
behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and …
Clocks not winding down: unravelling circadian networks
An intrinsic clock enables an organism to anticipate environmental changes and use energy
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …
Circadian molecular clocks and cancer
FC Kelleher, A Rao, A Maguire - Cancer letters, 2014 - Elsevier
Physiological processes such as the sleep-wake cycle, metabolism and hormone secretion
are controlled by a circadian rhythm adapted to 24 h day-night periodicity. This circadian …
are controlled by a circadian rhythm adapted to 24 h day-night periodicity. This circadian …