Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …

Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …

Programmed cell death is a key mechanism involved in several biological processes
ranging from development and homeostasis to immunity, where it promotes the removal of …

Respiratory diseases, always being a threat towards the health of people all over the world,
are most tightly associated with immune system. Neutrophils serve as an important …

All cells must die at some point, and the dogma is that they do it either silently via apoptosis
or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways …

Abstract Rationale: The role of Monosodium Urate (MSU) crystals in gout pathophysiology is
well described, as is the major impact of IL-1β in the inflammatory reaction that constitutes …

Inflammation is the host response to microbial infection or sterile injury that aims to eliminate
the insult, repair the tissue and restore homeostasis. Macrophages and the NLRP3 …