Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Nanoparticles and innate immunity: new perspectives on host defence
The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …
particulate materials. Engineered nanoparticles can interact with the immune system in …
Pyroptosis in neutrophils: multimodal integration of inflammasome and regulated cell death signaling pathways
GR Dubyak, BA Miller, E Pearlman - Immunological reviews, 2023 - Wiley Online Library
Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …
Specific NLRP3 inflammasome assembling and regulation in neutrophils: relevance in inflammatory and infectious diseases
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …
NET formation–mechanisms and how they relate to other cell death pathways
T Rosazza, J Warner, G Sollberger - The FEBS journal, 2021 - Wiley Online Library
Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …
death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form …
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis
Programmed cell death is a key mechanism involved in several biological processes
ranging from development and homeostasis to immunity, where it promotes the removal of …
ranging from development and homeostasis to immunity, where it promotes the removal of …
Advanced role of neutrophils in common respiratory diseases
J Liu, Z Pang, G Wang, X Guan, K Fang… - Journal of …, 2017 - Wiley Online Library
Respiratory diseases, always being a threat towards the health of people all over the world,
are most tightly associated with immune system. Neutrophils serve as an important …
are most tightly associated with immune system. Neutrophils serve as an important …
Approaching neutrophil pyroptosis
G Sollberger - Journal of molecular biology, 2022 - Elsevier
All cells must die at some point, and the dogma is that they do it either silently via apoptosis
or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways …
or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways …
[HTML][HTML] A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1β as relevant therapy for gout patients
A Mariotte, A De Cauwer, C Po, C Abou-Faycal… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Rationale: The role of Monosodium Urate (MSU) crystals in gout pathophysiology is
well described, as is the major impact of IL-1β in the inflammatory reaction that constitutes …
well described, as is the major impact of IL-1β in the inflammatory reaction that constitutes …
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
Inflammation is the host response to microbial infection or sterile injury that aims to eliminate
the insult, repair the tissue and restore homeostasis. Macrophages and the NLRP3 …
the insult, repair the tissue and restore homeostasis. Macrophages and the NLRP3 …