Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

DNA methylation inhibitors have become the mainstay for treatment of certain
haematological malignancies. In addition to their abilities to reactivate genes, including …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Abstract N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs
(carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and …

In animal embryos, transcription is mostly silent for several cell divisions, until the release of
the first major wave of embryonic transcripts through so-called zygotic genome activation …

Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …

The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Abstract N 6-methyladenosine (m6A) and its regulatory components play critical roles in
various developmental processes in mammals. However, the landscape and function of …