Mononuclear iron‐containing enzymes are highly versatile oxidants that often react
stereospecifically and/or regioselectively with substrates. Combined experimental and …

Hypoxia-inducible factor (HIF) is a central regulator involved in detection and adaption to
cellular oxygen stress through regulation of the hypoxic transcriptional program in …

Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …

The gut microbiota is essential for human health. Microbial supply of short-chain fatty acids
(SCFAs), particularly butyrate, is a well-established contributor to gut homeostasis and …

Human prolyl‐hydroxylases (PHDs) are hypoxia‐sensing 2‐oxoglutarate (2OG)
oxygenases, catalysis by which suppresses the transcription of hypoxia‐inducible factor …

Hypoxia inducible factors (HIFs) are oxygen dependent heterodimeric transcription factors
that mediate molecular responses to reductions in cellular oxygen (hypoxia). HIF signaling …

Hypoxia-inducible transcription factors (HIFs) facilitate cellular adaptations to low-oxygen
environments. However, it is increasingly recognised that HIFs may be activated in response …

Abstract JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian
regulation in plants and humans and is involved in embryonic development and cell …

Adaptation to chronic hypoxia occurs through changes in protein expression, which are
controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for cancer cell survival …

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are
targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is …