Obesity has become a worldwide epidemic, and its prevalence has been projected to grow
by 40% in the next decade. This increasing prevalence has implications for the risk of …

Chronic kidney disease (CKD) is a major public health problem. The classification of CKD by
KDOQI and KDIGO and the routine eGFR reporting have resulted in increased identification …

Obesity is associated with higher mortality in the general population, but this association is
reversed in patients on dialysis. The nature of the relationship of obesity with adverse …

Insulin resistance (IR) is an early metabolic alteration in chronic kidney disease (CKD)
patients, being apparent when the glomerular filtration rate is still within the normal range …

During the past 2 decades, results of both basic science and clinical studies have changed
the physicians' views about adipocyte pathophysiology. Since leptin was discovered in …

The relationship among insulin resistance, adiponectin, and cardiovascular (CV) morbidity
in patients with mild and moderate kidney disease was investigated. Insulin sensitivity …

The seemingly counterintuitive risk factor paradox is the hallmark of chronic disease states
or conditions associated with wasting disease at the population level. Studying similarities …

Mortality is markedly elevated in hemodialysis (HD) patients. Between 30 and 50% of
prevalent patients have elevated serum levels of inflammatory markers such as C-reactive …

Recent evidence points to molecules secreted by the adipose tissue, or adipokines, as
possible links between increased adipose mass and metabolic abnormalities. Among these …

In the present study, we explore the role of decreased renal function and a genetic
polymorphism on the recently discovered protein resistin, apparently able to inhibit hepatic …