Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
Antioxidant systems and oxidative stress in the testes
Spermatogenesis is an extremely active replicative process capable of generating approxi
mately 1,000 sperm a second. The high rates of cell division inherent in this process imply …
mately 1,000 sperm a second. The high rates of cell division inherent in this process imply …
[HTML][HTML] Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells
Z Sun, Y Wen, F Zhang, Z Fu, Y Yuan, H Kuang… - Ecotoxicology and …, 2023 - Elsevier
Plastic particle pollution poses an emerging threat to ecological and human health.
Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the …
Laboratory animal studies have illustrated that nano-sized plastics can accumulate in the …
Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells
J Ramalho-Santos, S Varum, S Amaral… - Human reproduction …, 2009 - academic.oup.com
BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …
A review on the impact of oxidative stress and medicinal plants on Leydig cells
E Monageng, U Offor, NB Takalani, K Mohlala… - Antioxidants, 2023 - mdpi.com
Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the
production of reactive oxygen species (ROS) and the cellular antioxidant level brings about …
production of reactive oxygen species (ROS) and the cellular antioxidant level brings about …
[HTML][HTML] Rat testicular impairment induced by electromagnetic radiation from a conventional cellular telephone and the protective effects of the antioxidants vitamins C …
MA Al-Damegh - Clinics, 2012 - Elsevier
OBJECTIVE: The aim of this study was to investigate the possible effects of electromagnetic
radiation from conventional cellular phone use on the oxidant and antioxidant status in rat …
radiation from conventional cellular phone use on the oxidant and antioxidant status in rat …
[HTML][HTML] Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
S Alboghobeish, M Mahdavinia, L Zeidooni… - Iranian journal of …, 2019 - ncbi.nlm.nih.gov
Objective (s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic
industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic …
industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic …
Butylated hydroxyanisole induces testicular dysfunction in mouse testis cells by dysregulating calcium homeostasis and stimulating endoplasmic reticulum stress
Butylated hydroxyanisole (BHA), a synthetic phenolic antioxidant (SPA), has been used as a
food additive. However, BHA acts as an environmental hormone, ie, endocrine disruptor …
food additive. However, BHA acts as an environmental hormone, ie, endocrine disruptor …
[HTML][HTML] Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition
M Wang, J Xu, Z Zhao, L Gong, Y Su, Z Fang… - Ecotoxicology and …, 2023 - Elsevier
Triphenyl phosphate (TPHP) is a widely used organophosphate flame retardant and has
biological toxicity. Previous studies showed TPHP can restrain testosterone biosynthesis in …
biological toxicity. Previous studies showed TPHP can restrain testosterone biosynthesis in …
Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells
DY Luo, G Yang, JJ Liu, YR Yang… - Asian journal of …, 2010 - pmc.ncbi.nlm.nih.gov
The aim of this study was to explore the effects of varicocele on the morphology and function
of Leydig cells in the rat testis. Forty male Sprague–Dawley rats were divided into two …
of Leydig cells in the rat testis. Forty male Sprague–Dawley rats were divided into two …