Tumor Organoids: The Era of Personalized Medicine

NV Rassomakhina, AY Ryazanova, AR Likhov… - Biochemistry …, 2024 - Springer
The strategies of future medicine are aimed to modernize and integrate quality approaches
including early molecular-genetic profiling, identification of new therapeutic targets and …

iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

ME Bogomiakova, EK Sekretova, KS Anufrieva… - Stem Cell Research & …, 2023 - Springer
Background Dozens of transplants generated from pluripotent stem cells are currently in
clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible …

Dysregulation of Immune Tolerance to Autologous iPSCs and Their Differentiated Derivatives

ME Bogomiakova, AN Bogomazova… - Biochemistry (Moscow …, 2024 - Springer
Induced pluripotent stem cells (iPSCs), capable of differentiating into any cell type, are a
promising tool for solving the problem of donor organ shortage. In addition, reprogramming …

Clinical grade human pluripotent stem cell-derived engineered skin substitutes promote keratinocytes wound closure in vitro

S Domingues, A Darle, Y Masson, M Saidani… - Cells, 2022 - mdpi.com
Chronic wounds, such as leg ulcers associated with sickle cell disease, occur as a
consequence of a prolonged inflammatory phase during the healing process. They are …

An Efficient 2D Protocol for Differentiation of iPSCs into Mature Postmitotic Dopaminergic Neurons: Application for Modeling Parkinson's Disease

OS Lebedeva, EI Sharova, DA Grekhnev… - International Journal of …, 2023 - mdpi.com
About 15% of patients with parkinsonism have a hereditary form of Parkinson's disease
(PD). Studies on the early stages of PD pathogenesis are challenging due to the lack of …

Specific cleavage of IGFBP-4 by papp-a in nervous tissue

GA Dya, OS Lebedeva, DA Gushchevarov… - Biochemical and …, 2024 - Elsevier
Astrocytes are subtypes of glial cells involved in metabolic, structural, homeostatic, and
neuroprotective processes that help neurons maintain viability. Insulin-like growth factors …

Исследование биораспределения тканеинженерного продукта на основе хондроцитов человека различного происхождения при имплантации мышам линии …

ПА Голубинская, АС Пикина, ЕC Ручко… - …, 2024 - journal.scbmt.ru
Аннотация Целью данной работы было исследовать биораспределение
разработанного нами продукта тканевой инженерии (ПТИ) на основе хондроцитов …

[PDF][PDF] IN VITRO ASSESSMENT OF IMMUNOGENICITY IN CHONDROCYTES OBTAINED FROM THE B2M KNOCKOUT INDUCED PLURIPOTENT STEM CELLS

AA Barinova, AS Pikina, PA Golubinskaya, ES Ruchko… - mes.fmba.press
The iPSCs (hereinafter, iPS) were cultured as previously reported [14]. The B2M knockout
iPS cell line (iPS_dB2M) was obtained earlier [15]. iPSC differentiation into chondrocyte-like …

[PDF][PDF] IN VITRO ОЦЕНКА ИММУНОГЕННОСТИ ХОНДРОЦИТОВ, ПОЛУЧЕННЫХ ИЗ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК С …

АА Баринова, АС Пикина, ПА Голубинская, ЕС Ручко… - mes.fmba.press
Funding: chondrocyte-like cells were obtained from iPSCs within the framework of the State
Assignment# 122032300191-2 “Organoid-22”. Immunocytochemical and PCR-based …