Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and meta-analysis

E Von Woon, O Greer, N Shah… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine natural killer cells (uNK) are the most abundant lymphocytes found
in the decidua during implantation and in first trimester pregnancy. They are important for …

[HTML][HTML] Sestrins induce natural killer function in senescent-like CD8+ T cells

BI Pereira, RPH De Maeyer, LP Covre… - Nature …, 2020 - nature.com
Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …

Uterine immunity and microbiota: a shifting paradigm

C Agostinis, A Mangogna, F Bossi, G Ricci… - Frontiers in …, 2019 - frontiersin.org
The female reproductive tract harbors distinct microbial communities, as in the vagina,
cervical canal, uterus, and fallopian tubes. The nature of the vaginal microbiota is well …

Involvement of novel adipokines, chemerin, visfatin, resistin and apelin in reproductive functions in normal and pathological conditions in humans and animal models

A Estienne, A Bongrani, M Reverchon, C Ramé… - International journal of …, 2019 - mdpi.com
It is well known that adipokines are endocrine factors that are mainly secreted by white
adipose tissue. Their central role in energy metabolism is currently accepted. More recently …

International union of basic and clinical pharmacology CIII: chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and …

AJ Kennedy, AP Davenport, EH Ohlstein - Pharmacological Reviews, 2018 - Elsevier
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous
ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as …

Role of distinct natural killer cell subsets in anticancer response

H Stabile, C Fionda, A Gismondi, A Santoni - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …

Immunological modes of pregnancy loss: inflammation, immune effectors, and stress

J Kwak‐Kim, S Bao, SK Lee, JW Kim… - American journal of …, 2014 - Wiley Online Library
Inflammatory immune response plays a key role in reproductive failures such as multiple
implantation failures (MIF), early pregnancy loss, and recurrent pregnancy losses (RPL) …

[HTML][HTML] Chemerin/chemR23 axis in inflammation onset and resolution

F Mariani, L Roncucci - Inflammation Research, 2015 - Springer
Chemerin is an adipokine secreted by adipocytes and associated with obesity, insulin
resistance and metabolic syndrome. Different chemerin fragments with pro-or anti …

Molecular mechanisms directing migration and retention of natural killer cells in human tissues

R Castriconi, P Carrega, A Dondero, F Bellora… - Frontiers in …, 2018 - frontiersin.org
A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a
potent cytolytic activity against tumors and virus infected cells. The discovery and …