Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells
Previously, we identified that AP-1 transcription factor FOSL1 is required to maintain cancer
stem cells (CSCs) in HNSCC, and an AP-1 inhibitor, T-5224, can eliminate HNSCC CSCs …
stem cells (CSCs) in HNSCC, and an AP-1 inhibitor, T-5224, can eliminate HNSCC CSCs …
[HTML][HTML] Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular …
Abstract The Department of Medicinal Chemistry, together with the Institute for Structural
Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has …
Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has …
Current Scenario of Pyridine/Quinoline-Sulfonamide Hybrids with Anticancer Potential (A Review)
GL Dong, YP Feng, JJ Wang, X Sun - Russian Journal of General …, 2024 - Springer
Cancer, which proliferates and spreads uncontrollably due to the accumulation of genetic
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
Analysis of quinolinequinone analogs with promising cytotoxic activity against breast cancer
AM Yilmaz Goler, A Tarbin Jannuzzi… - Chemistry & …, 2023 - Wiley Online Library
It is quite challenging to find out bioactive molecules in the vast chemical universe. Quinone
moiety is a unique structure with a variety of biological properties, particularly in the …
moiety is a unique structure with a variety of biological properties, particularly in the …
Copper (I)-Mediated Divergent Synthesis of Pyrroquinone Derivatives and 2-Halo-3-amino-1, 4-quinones
B Wang, H Xu, FY Li, JY Wang - The Journal of Organic Chemistry, 2023 - ACS Publications
A divergent transformation of 2-amino-1, 4-quinones for the synthesis of pyrroquinone
derivatives and 2-halo-3-amino-1, 4-quinones was disclosed. The mechanistic study …
derivatives and 2-halo-3-amino-1, 4-quinones was disclosed. The mechanistic study …
Synthesis, anti-inflammatory activity, inverse molecular docking, and acid dissociation constants of new naphthoquinone-thiazole hybrids
Chronic Inflammation is associated with various types of diseases that involves pro-
inflammatory cytokines like IL-6 and TNF-α. High costs and serious side effects of available …
inflammatory cytokines like IL-6 and TNF-α. High costs and serious side effects of available …