The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Lung cancer has the second highest incidence and highest mortality compared to all other
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …

Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Significance: Central nervous system (CNS) diseases are disorders of the brain and/or
spinal cord and include neurodegenerative diseases such as Alzheimer's disease …

Abstract Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from
endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided …

Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis.
Numerous phytochemicals derived from edible plants have been reported to interfere with a …

The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])–Keap1 (Kelch-like
erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling …